4.6 from 1,000+ reviews

Excellenton Trustpilot

AlexCo-Founder Alex · Why we started it ↓

Your gut issues keep coming back. There’s one part nothing on the shelf reaches.

The probiotic. The fibre. No bread. The tablets after dinner. It eases, then it’s back. It isn’t always what’s in your gut.

Vagus One is daily nutrition for the nerve that sets your digestion’s pace. Two capsules a day. Nothing to cut out.

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Developed with a medical and clinical advisory team

Or see why it keeps coming back

A woman with her hand on her stomach. A line runs from a knot in her gut up through her neck to her head.The nerve
behind itThe bloat
A woman asleep, lying flat in bed and smiling. The clock says quarter to seven, her water is untouched, Vagus One is on the bedside table and her dress from the night before is over the chair.“No cough, no throat clearing.”Mel J. · Trustpilot
Why it keeps coming back

Everything you’ve tried works on what’s in your gut.

  • Probioticsadd bacteria
  • Fibreadds bulk
  • Peppermintcalms a cramp for an hour
  • Antacidssettle acid that’s come up
  • Cutting foodstakes food away

Each does a real job. But every one works on what’s in your gut, not on the signal that tells your gut what to do with it.

Everything you’ve tried works on the acid.

  • Antacidssettle what’s come up
  • The daily tabletturns the acid down
  • Extra pillowslet gravity help
  • No late mealsleave less to come up
  • No coffee, no winetakes triggers away

Each does a real job. But every one works on the acid, not on the valve that keeps it down.

That leaves one part of digestion none of them reaches.

None of them works on the valve.

What you’ve tried
Tablets turn acid downAntacids, the daily tablet
What none of it reaches
A valve keeps it downThe ring at the top of your stomach
A nerve has a hand in the valveThe vagus nerve
Where Vagus One comes in
The nerve runs on nutrientsTwo capsules a day, with a meal
If this sounds familiar

You’ve done it all by the book.

It didn’t start as anything much.

A bit of burning after a big dinner. A cough you put down to a cold that never quite cleared.

So you did the sensible things.

The chalky stuff in every coat pocket. Then the daily tablet.

No coffee. No wine. Nothing to eat after seven.

A second pillow. Then a third.

And somewhere along the way, a few months became a few years.

Now you clear your throat through every conversation. You know which side to sleep on. You read the menu twice before you say yes to dinner out.

Here’s the part that wears you down.

You’ve kept every rule. And it still finds you, most nights, the moment your head goes down.

So you start to believe this is just how it is now.

But what if it keeps coming back because everything you’ve tried was aimed at the wrong thing?

Why I started Yona

Reflux woke me up night after night. Then I found the nerve behind it.

In 2024, my gut fell apart.

For months I couldn’t sleep. I’d wake up again and again through the night, with reflux or a pain in my stomach. It was unbearable.

So I tried everything on the market. Every kind of probiotic. Elimination diets. Digestive enzymes. Gluten-free, dairy-free.

Some of it helped for a few days. Then I was back to square one.

Everyone pointed me to medication. I wasn’t ready to accept that was the end of it. I knew there had to be another way.

So I started digging. I worked with gut health practitioners and nutritionists, and took test after test, trying to work out what was actually wrong.

Then I came across the vagus nerve, and how much of the gut it runs. My first thought was: how have I never heard of this?

That’s where it started. I learned how to support the nerve, and slowly but surely, my gut settled.

I stopped fearing food. I put weight back on. I got my confidence back.

Alex running at sunset
Back to feeling like me.

And I kept thinking: if this helped me, why is nobody talking about it?

Alex
AlexCo-Founder, Yona

Here’s what I found.

The part they don’t reach Why it keeps coming back

Your gut does the moving. A nerve sets the pace.

Acid stays down while a valve stays shut.

Everything you’ve tried works on the acid. None of it works on the valve that keeps it down.

Here’s what happens after dinner.

The food pipe running into the stomach, with the valve drawn as a ring where they meet and a nerve running down to it.The nerveThe valve
1 of 5
  1. That burn in your chest after dinner.
  2. It starts at a valve on top of your stomach.
  3. When the valve opens at the wrong moment, acid comes up.
  4. The vagus nerve has a hand in when it shuts.
  5. When it shuts on cue, acid stays put.

The vagus nerve is the main line between your brain and your gut, and the valve takes part of its cue from it.1 A very full stomach pushes on the valve too, which is why a big dinner and lying down soon after hit hardest. It’s also why the tablets can turn the acid down and the burn still comes back: the valve is a different job.

The main line from your brain to your gut is called the vagus nerve.1 It carries the “rest and digest” signal: when to start, how fast, when to ease off.

The digestive tract with three numbered points: 1 at the top of the stomach, 2 in the stomach, 3 in the intestines.
  1. 1 · TopThe lid

    The lid at the top of your stomach should stay shut. When it doesn’t, acid comes back up. That’s the burn after dinner, the cough that won’t clear, the night spent sitting up.

  2. 2 · MiddleThe emptying

    Your stomach should empty in good time. When it doesn’t, food sits there and you swell.

  3. 3 · BottomThe pace

    Your gut should move things along at a steady pace. Too slow, and the days go by. Too fast, and you’re looking for the nearest loo.

One nerve has a hand in all three.1

And you’ve felt it turn down. It’s worse in a hard week, whatever you eat.2 When your body is braced, digestion waits.

Vagus One is daily nutrition for that nerve. Two capsules a day, with a meal.

Two jobs, not one

Turning the acid down isn’t keeping it down.

Awake at ten past two, propped up on pillows, hand on her chest.

Turn the acid down

  1. 01

    Tablets and the chalky stuff

  2. 02

    Less acid

  3. 03

    The burn calms down

  4. 04

    The valve still opens when it shouldn’t

Calms the burn for now. But the valve is left to itself.

Asleep, lying flat, with the nerve drawn from behind her ear to a closed valve.

Aim at the root cause

  1. 01

    Support the vagus nerve

  2. 02

    It tells the valve when to close

  3. 03

    The valve closes when it should

  4. 04

    Acid stays down where it belongs

Aims at why the acid comes up in the first place.

Most people have only ever been offered the first job. Nobody mentioned the second.

The root cause

So why does the nerve stop telling the valve to close?

Three things wear it down.

The first is the way we live now. Your body runs in two settings: braced, ready for whatever’s coming, and rest and digest, the setting the vagus nerve runs. The valve belongs to the second.

Think about an ordinary week. Meals eaten standing up. The phone in bed. Worrying about the people you look after. Waking at three and lying there. Every one of those keeps you braced.

The second is the years. The vagus nerve tends to get quieter as we get older.

The third is the way we eat now. More than half of what we eat in the UK is ultra-processed. And to tell the valve to close, the nerve uses a messenger: a chemical called acetylcholine, which has to be made every day from what you eat.

On average, adults get less of the nutrient it’s made from than is recommended.

You were never told any of this. You were told to turn the acid down. This is the missing piece if you’ve tried everything else.

And a nerve that makes its message from what you eat can be fed.

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Not sure yet? Here’s what happened when people started feeding the nerve.

What happened next

I didn’t think it would help anyone but me.

Once my own gut had settled, I set out to build a formula for everyone else, with nutritionists alongside me. That’s how Yona was born.

To be honest, I was still sceptical. What worked for me might not work for anyone else.

We launched small, with a beta test. Then the first review came in.

“Within the first week I felt a massive difference and have continued using these daily… I have also tried so many “gut health” products over the years and I can honestly say this one has hit the mark for me.”

One of our first reviews

I was shocked, and so happy. But I thought it might be a lucky one. Then more came in.

“At first very sceptical about anything actually helping my gut issues, I am pleased to find that I am finding my gut is calmer and my usual symptoms have eased!!! To be honest, I’m amazed!”

An early review

It wasn’t all good news. A few early customers found it didn’t agree with them. So we went back to the research, improved the formula and launched again. Now we suggest that anyone sensitive starts slowly, with one capsule a day for the first few days, and gives it the full three months.

We’re not perfect, and Yona isn’t for everyone. But for the people it helps, it can make a massive difference.

Two years on, we’re still refining it. We’re only getting started.

Alex
AlexCo-Founder, Yona
What to do about it

A nerve has to be fed. So we built what it runs on.

To keep the line to your gut working, the nerve needs three things: fuel, building blocks and a calm state. Vagus One is all three, in one formula. Nine nutrients, each with a job. Two capsules a day, with a meal.

The valve answers to a signal. The signal runs on nutrients.

The muscle that keeps acid down takes part of its cue from your nerves. That cue travels on a messenger your nerves build from what you eat, and sending it takes energy. Vagus One is daily nutrition for that signal. Two capsules with a meal.

Vagus One bottle and two capsules on a stone plinth.
What the signal needs
What Vagus One gives it
Energy, to send it
Four nutrients for the nerve’s own energy supply, in forms your body can use.
The messenger itself
Three nutrients: both halves of the messenger, and what joins them.
A calm moment, so it lands
Two more, for the state you sit down to eat in.
Every meal, every day
All nine in one formula, balanced to work together.
What the nerve needs
What Vagus One gives it
Fuel, to power the line
Four nutrients for the nerve’s own energy supply, in forms your body can use.
Building blocks, to make the messenger
Three nutrients: both halves of the messenger, and what joins them.
A calm state, so the message lands
Two more, for the state you sit down to eat in.
Every link, every day
All nine in one formula, balanced to work together.

Claim your nights back

Ten years of gut issues
“Less bloating, less indigestion, but most importantly less food reactions and being able to just eat a variety of foods in peace… The longer I take it, the better I feel. I’ve been taking it for several months now.”
Yvonne M. · Yona customer, in her own words
After many, many years
“It’s been a few months now since I started Yona, and I’ve noticed a remarkable improvement. No need for PPIs… It’s a revelation for me, who has been a constant sufferer for many, many years.”
Yona customer · On camera, in her own words
Real Yona customers

Thousands now eating with food freedom.

Most of them came to us for reflux.

More than four in five customers in our survey had acid or silent reflux when they started. Here’s what some of them say now.

Rated Excellent on Trustpilot

“I can eat anything I want”

I was suffering from acid reflux very often, sometimes I was choking in the middle of the night… I can eat anything I want without thinking about acid reflux.
Saintia M. · Trustpilot, April 2026

“Able to sleep lying down”

I have suffered with LPR (silent reflux) for 2 to 3 years… I’ve been taking them for around four months and I am now able to sleep lying down… most of the time.
Alison · Trustpilot, April 2026

“No cough, no throat clearing”

Having lived with LPR for 10 years, I’d lost all hope… No cough, no throat clearing and so, so happy.
Mel J. · Trustpilot, December 2025

“Night time reflux is much reduced”

I’ve tried all sorts of remedies over the years but for the first time in years I feel that this might actually help… night time reflux is much reduced.
Liz H. · Trustpilot, October 2025

“It took a few months, but I’d had it for years”

Great product that reduced my acid reflux massively. It took a few months, but I’d had it for years.
Mary H. · Trustpilot, June 2026

“Symptom free for the majority of the time”

I’ve now been on the supplement for silent reflux for a number of months. My symptoms have definitely improved. I’m now symptom free for the majority of the time… Don’t expect a fast cure but I do think it helps.
Sara · Trustpilot, May 2026

“The only product I’ve found that’s helped”

The only product I’ve found that’s helped my acid reflux. Also wonderful customer service.
Caroline S. · Trustpilot, March 2026

“Less bloating. A lot calmer.”

Within the first week I felt a massive difference and have continued using these daily. I have less bloating… Feeling a lot calmer too.
Kathleen M. · Verified review

“I’d had this problem for YEARS”

I have been taking these capsules for a few months to try and stop my excessive burping and after the second/third bottle I realised I’d virtually stopped burping completely.
LBM · Trustpilot, June 2026

“Nerves, stomach, sleep: all improved”

I was skeptical that this product could support me, but on reflection my general regulation — nerves, stomach, sleep — have all improved and I’ve felt supported.
Jules Z. · Verified review, April 2026

“I can feel the difference”

I have been taking it for nearly a month and I can feel the difference… less bloating, and don’t seem to get any acid indigestion.
Sally S. · Verified review

“Much more settled after 6 weeks”

I didn’t think this would work. I was very suspicious. However after 6 weeks I am much more settled and don’t have the gut issues.
Jane J. · Verified purchase

“A meal without the panic”

…to be able to have a meal and not panic about feeling uncomfortable afterwards.
Liz H. · Verified review

Individual experiences vary.

From a former NHS doctor

“I watched patients stay on acid tablets for years longer than anyone planned. Nobody was asking what came next.”

Acid-suppressing tablets are good medicine. They turn the acid down fast, and at first that’s often exactly what’s needed.

But they were meant to manage reflux, not to be the whole plan. NICE guidance says long-term use should be reviewed every year. In clinic, I kept meeting people who’d been on them for years without that conversation ever happening.

Long-term use isn’t free, either. The MHRA has warned about low magnesium and a higher risk of fractures with prolonged use. Most of the people I saw had never been told.

Don’t stop anything you’ve been prescribed. Do ask your GP for a review. And while you’re at it, feed the part of digestion no tablet reaches.

Sana MisraFormer NHS doctor
From a former NHS doctor

“As an NHS doctor, I treated bloating and bad sleep as two separate problems. I was wrong.”

Medicine is built to find disease, and it’s brilliant at it. But when nothing is seriously wrong, you get a fix for each symptom. Something for the gut. Something for sleep. Each treated as if the other didn’t exist.

Then I saw what they had in common. Digestion that changed with stress. Sleep that fell apart when people couldn’t unwind. Different symptoms, one trigger.

That isn’t a gut problem or a sleep problem. It’s a nervous system problem.

And the nerve that links them is the vagus nerve. More and more people are running short of the nutrients it needs.

That’s what led us to build Yona.

Sana MisraFormer NHS doctor
The clinicians who advise us
Dr Alisha Damani
Dr Alisha Damani
MBChB· Clinical adviser

Specialises in autonomic nervous system function and its effect on digestive health: the exact biology Vagus One is built around.

David McCollum
David McCollum
Cert Nat ANP· Clinical nutritionist

Twenty-five years in clinical nutrition, working with people who haven’t responded to conventional approaches.

Introducing Vagus One

Aimed at the root cause of reflux. So you get your days and nights back.

I didn’t set out to make another reflux supplement. I set out to feed the nerve that settled my own gut.

Most of what you’ve tried turns the acid down. Vagus One supports the nerve that tells your valve when to close.

Only the best-quality ingredients we could find, and every one is tested before it goes into a capsule.

The Vagus One bottle floating in open sky, with capsules, saffron threads and crystals around it.
  1. Feeds the root cause.

    What the nerve needs to tell your valve when to close, every single day.

  2. Helps you switch off after dinner.

    So your body can drop into rest and digest, the setting your valve belongs to.

  3. Less tiredness, more energy.

    For the mornings after the bad nights.

How it’s made

And it exists because I couldn’t find anything that fed the nerve properly, so I built it with nutritionists.

Alex
AlexCo-Founder, Yona
All nine ingredients, per 2 capsules
Citicoline
250 mg
Acetyl-L-carnitine
300 mg
Pantothenic acid
100 mg
Benfotiamine
200 mg
Thiamine
25 mg
Riboflavin
10 mg
L-theanine
150 mg
Saffron extract
30 mg
Magnesium (bisglycinate)
60 mg

Per 2 capsules. Vegan capsule. No fillers, binders or artificial additives.

40+ peer-reviewed studies behind the formula, 19 of them in people.

Studies of the ingredients, not of Vagus One.

How it’s different

Vagus One vs the usual fixes.

What it doesVagus OneTablets & antacidsProbiotics
Aimed at the nerve behind the valve✓✕✕
Helps you switch off after dinner✓✕✕
Less tiredness, more energy✓✕✕
No fillers, bulking agents or sugar✓✕Some

Compared with typical tablets, antacids and probiotic supplements. “Some” means a few do, most don’t.

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In their words

Hear it from the people taking it.

Videos from Yona customers, including Vagus+, the formula Vagus One grew out of. Individual experiences vary.

Reader offer · only on this page

Claim your nights back. Readers pay less.

On this page only: a discount on your first order.

High demand this season. Order now to avoid delays with your order.

Free UK delivery · arrives in 2–3 working days

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Questions before you order? Message us on WhatsApp

With the Eat-Again Plan

Your Free Welcome Kit

£35 value · free with 90 days
  1. 1
    The only 3 night rules worth keeping

    A one-page guide to the three habits worth keeping, and permission to drop the rest.

  2. 2
    What to expect, week by week

    What’s normal across your 90 nights, so you know you’re on track.

  3. 3
    Your start in the Lie-Flat Nights programme

    How your 90 nights run, with a real person checking in at weeks 2, 6 and 12.

Sent by email the day your plan ships. Nothing to buy, nothing to cut out.

The 90-Night Promise

We’re confident enough in Vagus One to take the risk off you. Take it every day for 90 days. If nothing has changed, we’ll refund your first 90-day supply. There’s nothing to send back.

Email hello@meetyona.co.uk between day 90 and day 120, then answer a few short questions about how you took it.

90-Night Promise: full terms

Our 90-Night Promise

Your first 90-day supply of Vagus One is covered by our 90-Night Promise. Take it every day, as directed, for the full 90 days. If nothing has changed, we’ll refund what you paid for that first 90-day supply. You don’t need to send anything back.

The promise covers the 90-day supply (a bottle and two refills) only; 1 bottle and the bottle with a refill are outside it. It covers your first 90-day supply, not later orders or subscription renewals.

How to claim

  1. Your 90 days start the day your order arrives.
  2. Between day 90 and day 120, email hello@meetyona.co.uk with your full name and the email address you used to order.
  3. Answer a few short questions about how you took it.
  4. We refund what you paid for your first 90-day supply to your original payment method.

Good to know

  • Delivery charges are not refunded.
  • On a subscription, your next delivery is billed about three months after you order. If you’re planning to claim, skip or cancel it first.

Your legal rights

This promise is in addition to your legal rights as a consumer. It doesn’t affect them.

Questions?

Email hello@meetyona.co.uk and we’ll get back to you as soon as we can.

4.6 from 1,000+ reviews

ExcellentTrustpilot

  • “I was suffering from acid reflux very often, sometimes I was choking in the middle of the night… I can eat anything I want without thinking about acid reflux.”

    Saintia M. · April 2026

  • “Prior to using this I had frequent heartburn and trouble sleeping and using anti acids frequently. Since using Yona… have hardly used any anti acids so extremely pleased with results.”

    Don W. · June 2026

  • “I have been taking these capsules for a few months to try and stop my excessive burping and after the second/third bottle I realised I’d virtually stopped burping completely. I’ve had this problem for YEARS…”

    LBM · June 2026

  • “…it covered many of the issues affecting my health namely anxiety, acid reflux, insomnia and IBS type symptoms (that is a lot for one/two small tablets a day).”

    Caryl D. · August 2026

  • “I started taking the Yona vagus nerve tablet 2 months ago. And I can honestly say it’s changed my life… I take the tablet every morning with my breakfast.”

    Rachel W. · June 2026

  • “The company is outstanding in its customer care and service and the products actually work!”

    Jay A. · April 2026

  • “Great product… Definitely helped calm the vagus nerve and stomach issues.”

    George · April 2026
After many, many years
“It’s been a few months now since I started Yona, and I’ve noticed a remarkable improvement. No need for PPIs… It’s a revelation for me, who has been a constant sufferer for many, many years.”
Yona customer · On camera, in her own words
If you’re on the tablets Nearly 2 in 3

customers who were taking acid medication when they started told us they have since reduced it or stopped it.

From our 2026 customer survey, self-reported. That’s what they told us, not advice from us: keep taking anything you’ve been prescribed, and make any change with your GP.
The science

Over a century of research. One daily formula.

Vagus One is built on what physiology has known for more than a hundred years about the nerve that runs your digestion.

  1. 1921Your gut’s nerve has a messenger.

    Otto Loewi shows that the vagus nerve signals chemically. The messenger is acetylcholine, and the work wins a Nobel Prize.3

  2. 1943That messenger is built from nutrients.

    Acetylcholine is shown to be made from choline and an acetyl group. Later work ties that acetyl group to vitamins B1 and B5.4

  3. 2000sThe ingredients are tested in people.

    Citicoline, saffron and L-theanine go through randomised, placebo-controlled human trials.

What the research shows

Citicoline · 250 mg

In a double-blind trial of 60 women aged 40 to 60, 250 mg a day meant fewer attention errors than placebo after 28 days.5

Read the study
Saffron · 30 mg

In a double-blind trial of 128 adults, 28 mg a day improved mood scores against placebo. In a second trial at 30 mg, heart-rate variability held steady during a lab stress test, where it dropped on placebo.6

Study one Study two
Benfotiamine · 200 mg

In a human absorption study, benfotiamine raised blood thiamine far higher than standard thiamine.7

Read the study

40+ peer-reviewed studies behind the formula, 19 of them in people.

Claim your nights back
Questions

Questions people actually ask.

Will it work for me?
For most of our customers, digestion gets better: in our customer survey, four in five reported better digestion. Vagus One works on the nerve side of digestion. The vagus nerve sets the pace of your gut, from stomach acid to the waves that move a meal along, and it runs on specific nutrients. Vagus One supplies them every day. And your first 90-day supply comes with our money-back promise, so you can start with confidence.
I take a daily tablet for acid. Is this instead of it?
No. Vagus One is a food supplement, not a medicine, and it doesn’t replace one. They work on different things: your tablet works on the acid, Vagus One is nutrition for the nerve side of digestion. Keep taking what you’ve been prescribed, and check with your GP or pharmacist before adding a supplement. Many of our customers were on acid medication when they started. Any change to yours is a decision for you and your GP.
How long until I notice a difference?
Most people who notice a change feel it within the first four weeks. It builds from there, because you’re supplying what the nerve runs on rather than forcing a response. That’s why Vagus One is designed as a 90-day routine.
When’s the best time to take it?
Two capsules daily, with a meal. If you’re sensitive to supplements, start with one capsule a day for the first few days.
Do I need to change what I eat?
No. A varied, balanced diet comes first, and if a food genuinely disagrees with you, keep avoiding it. Vagus One doesn’t ask you to cut anything out.
Can I take it with medication or other supplements?
Speak to your doctor or pharmacist first if you take prescription medication, are pregnant or breastfeeding, are under 18 or have a diagnosed condition. Check the amounts across any other supplements you use.
How long does delivery take?
Orders are sent from the UK and usually arrive in 2–3 working days. UK delivery is free. You’ll get an email when your order is on its way. Need it sooner? Next-working-day delivery is £4.69 at checkout.
What comes with the Eat-Again Plan?

Free Welcome Kit. By email the day your plan ships: the only 3 night rules worth keeping, and what to expect week by week.

Lie-Flat Nights programme. Short, practical tips across your 90 nights, with a real person checking in at weeks 2, 6 and 12.

WhatsApp a clinical nutritionist. A real person, six days a week, for how to take it, food, timing and your routine. They don’t diagnose or change anything you’ve been prescribed. The number is in your welcome email.

All three come with both 90-day options.

How does the 90-Night Promise work?
Take Vagus One every day for 90 days from delivery. If nothing has changed, email us between day 90 and day 120, answer a few short questions, and we’ll refund what you paid for that supply. There’s nothing to send back. The promise covers your first 90-day supply; 1 bottle and the bottle with a refill aren’t included.

Feed the nerve and claim your nights back.

Two capsules with a meal. Nothing to stop taking, nothing to cut out.

Claim your nights back

Arrives in 2–3 working days

P.S. Two years ago, I was the one awake at night, wondering if this was just how it was going to be. If you’re reading this after another broken night, I know exactly how that feels. Start slowly, give it the full 90 nights, and tell us how you get on. — Alex

References
  1. Overton E, Emelyanova A, Bunik VI. Thiamine, gastrointestinal beriberi and acetylcholine signaling. Frontiers in Nutrition. 2025;12:1541054. PubMed 40271433. Browning KN, Travagli RA. Central nervous system control of gastrointestinal motility and secretion. Comprehensive Physiology. 2014. PubMed 25428846.
  2. Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. Journal of Physiology and Pharmacology. 2011. PubMed 22314561.
  3. Loewi O. Über humorale Übertragbarkeit der Herznervenwirkung. Pflügers Archiv. 1921;189:239–242. doi:10.1007/BF01738910.
  4. Nachmansohn D, Machado AL. The formation of acetylcholine. A new enzyme: “choline acetylase”. Journal of Neurophysiology. 1943;6(5):397–403. doi:10.1152/jn.1943.6.5.397.
  5. McGlade E, Locatelli A, Hardy J, et al. Improved attentional performance following citicoline administration in healthy adult women. Food and Nutrition Sciences. 2012;3(6):769–773. doi:10.4236/fns.2012.36103.
  6. Kell G, Rao A, Beccaria G, et al. affron®, a novel saffron extract, improves mood in healthy adults over 4 weeks. Complementary Therapies in Medicine. 2017;33:58–64. doi:10.1016/j.ctim.2017.06.001. Jackson PA, Forster J, Khan J, et al. Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults. Frontiers in Nutrition. 2021;7:606124. doi:10.3389/fnut.2020.606124.
  7. Xie F, Cheng Z, Li S, et al. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. Journal of Clinical Pharmacology. 2014;54(6):688–695. doi:10.1002/jcph.261.

Cited as published research on the underlying biology, not as studies of Vagus One. Survey figures are self-reported: 128 responses from Yona customers, 2026.

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