Science You Can Feel

The gastrointestinal (GI) tract has its own complex nervous system, the enteric nervous system (ENS), often called the "second brain." While the ENS operates independently, it is influenced by the autonomic nervous system (ANS) through the sympathetic and parasympathetic branches. The vagus nerve, a key player in this system, is responsible for stimulating digestion, maintaining gut barrier integrity, and dampening inflammation.

Thiamine (Vitamin B1) is crucial for the proper functioning of the vagus nerve and, by extension, the entire GI system. A deficiency in thiamine can cause significant disruptions in the brain regions that control the ANS, leading to widespread dysfunction across bodily systems, including the GI organs.

We’re not into fads or quick fixes

In the gut, thiamine deficiency causes several specific issues...

Acetylcholine Production

Thiamine is essential for synthesizing acetylcholine, a neurotransmitter that drives gut motility. Low thiamine levels reduce acetylcholine, leading to impaired motility, delayed gastric emptying, bloating, and reflux. And importantly, CDP Choline is necessary for the production of Acetylcholine.

Stomach Acid Production

Thiamine deficiency inhibits hydrochloric acid secretion in the stomach, resulting in hypochlorydria (low stomach acid). This condition hampers protein digestion and increases the risk of bacterial overgrowth.

Digestive Enzymes

The pancreas, which stores a significant amount of thiamine, produces fewer digestive enzymes when thiamine is deficient. This leads to poor digestion, evident in undigested food in stools.

Nutrient Absorption

Thiamine deficiency also reduces the activity of enzymes in the intestinal brush border that are essential for breaking down food and absorbing nutrients. Without these enzymes, key vitamins like B6, B2, and even B1 itself cannot be absorbed, leading to a vicious cycle of malnutrition.

Numerous Studies On Our Formulations

https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00049/full

https://www.sciencedirect.com/science/article/abs/pii/S0002916523158783?via%3Dihub

https://jnnp.bmj.com/content/71/3/357