4.6 from 1,000+ reviews

Your gut issues keep coming back. There’s one part nothing on the shelf reaches.

The probiotic. The fibre. No bread. The tablets after dinner. It eases, then it’s back. It isn’t always what’s in your gut.

Vagus One is daily nutrition for the nerve that sets your digestion’s pace. Two capsules a day. Nothing to cut out.

Try Vagus One

From £25 · Free UK delivery

Or see why it keeps coming back

A woman with her hand on her stomach. A line runs from a knot in her gut up through her neck to her head.The nerve
behind itThe bloat
A woman propped up in bed on three pillows, a hand on her stomach. A line runs from her temple down her neck to a knot below her chest.The nerve
behind bothThe burn,
the cough

Developed with a medical and nutrition advisory team.

Why it keeps coming back

Everything you’ve tried works on what’s in your gut.

  • Probioticsadd bacteria
  • Fibreadds bulk
  • Peppermintcalms a cramp for an hour
  • Antacidssettle acid that’s come up
  • Cutting foodstakes food away

Each does a real job. But every one works on what’s in your gut, not on the signal that tells your gut what to do with it.

Everything you’ve tried works on the acid.

  • Antacidssettle what’s come up
  • The daily tabletturns the acid down
  • Extra pillowslet gravity help
  • No late mealsleave less to come up
  • No coffee, no winetakes triggers away

Each does a real job. But every one works on the acid, not on the valve that keeps it down.

That leaves one part of digestion none of them reaches.

None of them works on the valve.

What you’ve tried
Tablets turn acid downAntacids, the daily tablet
What none of it reaches
A valve keeps it downThe ring at the top of your stomach
A nerve has a hand in the valveThe vagus nerve
Where Vagus One comes in
The nerve runs on nutrientsTwo capsules a day, with a meal
The part they don’t reach

Your gut does the moving. A nerve sets the pace.

Acid stays down while a valve stays shut.

There’s a valve at the top of your stomach. While it stays shut, acid stays where it belongs. When it opens at the wrong moment, acid comes back up: the burn after dinner, the cough that won’t clear, the night spent sitting up.

The food pipe running into the stomach, with the valve drawn as a ring where they meet and a nerve running down to it.The nerveThe valve

That valve takes part of its cue from a nerve: the vagus nerve, the main line between your brain and your gut.1 A very full stomach pushes on it too, which is why a big dinner and lying down soon after hit hardest.

Two panels. Left: the valve at the top of the stomach is shut. Right: it opens and wisps rise from the stomach into the food pipe.Valve shutValve opens

The main line from your brain to your gut is called the vagus nerve.1 It carries the “rest and digest” signal: when to start, how fast, when to ease off.

The digestive tract with three numbered points: 1 at the top of the stomach, 2 in the stomach, 3 in the intestines.
  1. 1 · TopThe lid

    The lid at the top of your stomach should stay shut. When it doesn’t, acid comes back up. That’s the burn after dinner, the cough that won’t clear, the night spent sitting up.

  2. 2 · MiddleThe emptying

    Your stomach should empty in good time. When it doesn’t, food sits there and you swell.

  3. 3 · BottomThe pace

    Your gut should move things along at a steady pace. Too slow, and the days go by. Too fast, and you’re looking for the nearest loo.

One nerve has a hand in all three.1

And you’ve felt it turn down. It’s worse in a hard week, whatever you eat.2 When your body is braced, digestion waits.

It’s not just the burning.

What you want back is ordinary: dinner, then bed, then sleep.

What to do about it

A nerve has to be fed. So we built what it runs on.

To keep the line to your gut working, the nerve needs three things: fuel, building blocks and a calm state. Vagus One is all three, in one formula. Nine nutrients, each with a job. Two capsules a day, with a meal.

The valve answers to a signal. The signal runs on nutrients.

The muscle that keeps acid down takes part of its cue from your nerves. That cue travels on a messenger your nerves build from what you eat, and sending it takes energy. Vagus One is daily nutrition for that signal. Two capsules with a meal.

Vagus One bottle and two capsules on a stone plinth.
What the signal needs
What Vagus One gives it
Energy, to send it
Four nutrients for the nerve’s own energy supply, in forms your body can use.
The messenger itself
Three nutrients: both halves of the messenger, and what joins them.
A calm moment, so it lands
Two more, for the state you sit down to eat in.
Every meal, every day
All nine in one formula, balanced to work together.
What the nerve needs
What Vagus One gives it
Fuel, to power the line
Four nutrients for the nerve’s own energy supply, in forms your body can use.
Building blocks, to make the messenger
Three nutrients: both halves of the messenger, and what joins them.
A calm state, so the message lands
Two more, for the state you sit down to eat in.
Every link, every day
All nine in one formula, balanced to work together.

See the offer

Ten years of gut issues
“Less bloating, less indigestion, but most importantly less food reactions and being able to just eat a variety of foods in peace… The longer I take it, the better I feel. I’ve been taking it for several months now.”
Yvonne M. · Yona customer, in her own words
After many, many years
“It’s been a few months now since I started Yona, and I’ve noticed a remarkable improvement… It’s a revelation for me, who has been a constant sufferer for many, many years.”
Yona customer · On camera, in her own words
Before you order

This is for you if…

If you’re on the tablets Nearly 2 in 3

customers who were taking acid medication when they started told us they have since reduced it or stopped it.

From our 2026 customer survey, self-reported. That’s what they told us, not advice from us: keep taking anything you’ve been prescribed, and make any change with your GP.

See your GP first if you have blood in your stools, unexplained weight loss, trouble swallowing, severe or lasting pain, or a lasting change in bowel habit.

See your GP first if you have trouble swallowing, unexplained weight loss, blood when you’re sick or in your stools, or a cough or heartburn that has lasted three weeks and hasn’t been checked.

The 90-day plan

Feed the nerve for 90 days.

One bottle and two refills: ninety days of nutrition for the nerve, backed by our money-back promise.

The Vagus One 12-week box: one bottle, two refill pouches, the guided plan and a QR card.
A woman holding a Vagus One bottle and a capsule. The image reads: your nervous system needs nutrition too.
A woman with a line of light traced from her head down her neck. The image reads: your brain and body never stop talking.
A Vagus One bottle between a high-alert side and a rest side. The image reads: your body has an on state, it also needs a way back.
A Vagus One bottle being put into a handbag. The image reads: in your bag, for busy days.
An open Vagus One bottle with its lid and three capsules beside it.
Tried everything for your reflux? It was never just the acid. All of it manages the acid. None of it feeds the nerve.
Keeping acid down starts higher up. A valve at the top of your stomach keeps acid in. A nerve has a hand in it. Vagus One is daily nutrition for that nerve.
A nerve has to be fed, so we built what it runs on: fuel, building blocks and a calm state. Nine nutrients. Two capsules a day.
What customers with reflux told us: 81% reported an improvement, 61% said their reflux had reduced, 64% of those on acid medication had reduced or stopped it. Self-reported survey, 2026.
A recent Yona review, five stars: I can eat anything I want. Saintia M., Trustpilot.
A Yona customer on camera: It’s a revelation for me, who has been a constant sufferer for many, many years.
Weeks, not nights. Day 1: two capsules with a meal. Weeks 1 to 4: when most people first notice a change. Day 90: nothing changed, your money back.
Just 2 capsules a day, with a meal. Keep taking your tablets. Nothing to cut out.
Developed with a medical team: Sana Misra, former NHS doctor; Dr Alisha Damani, clinical adviser; David McCollum, clinical nutritionist.
4.6from 1,000+ reviews

Yona has sold out 5 times in the past year

Vagus One

Daily nervous-system nutrition, designed around the biology of the vagus nerve.

  • Feeds the nerve that sets your gut’s pace
  • Eat with more confidence: four in five customers surveyed reported better digestion
  • Two capsules a day. Nothing to cut out.
1. Choose your supply
2. Your order
Today’s total£42.00Free UK delivery · usually 2–3 days
What arrives, renewal and guarantee
What arrives
Vagus One: one bottle, 60 capsules (30 days).
Renewal
Nothing renews. One payment, no subscription.
Guarantee
The 90-day money-back promise comes with the 90-day supply.

Secure checkout

Visa Mastercard American Express Apple Pay Google Pay PayPalShop Pay Klarna
  • Pause or cancel anytime
  • Third-party tested, every batch
  • Vagus One: vegan, no fillers

Questions before you order? Message us on WhatsApp

“The only product I’ve found that’s helped my acid reflux.”

Caroline S · Trustpilot review

“My general regulation — nerves, stomach, sleep — have all improved.”

Jules Z · Verified review
The 90-day promise

A full 90 days. One simple routine.

Your 90 days start when your order arrives. Take it every day for the full 90 days. If nothing has changed, email hello@meetyona.co.uk between day 90 and day 120 and answer a few short questions about how you took it.

We’ll refund what you paid for your first 90-day supply. You don’t need to send anything back.

Read the full promise

The 90-day promise applies to the 90-day supply only; the 30-day supply is outside it. Your 90 days start the day your order arrives. Take Vagus One every day, as directed, for the full 90 days. If nothing has changed, email hello@meetyona.co.uk between day 90 and day 120 and answer a few short questions about how you took it.

We’ll refund what you paid for your first 90-day supply. You don’t need to send anything back. On a subscription, your next delivery is billed about three months after you order; if you’re planning to claim, skip or cancel it first. Your statutory rights are unaffected.

CoversYour first 90-day supply
StartsWhen your order arrives
Claim windowDay 90 to day 120
ReturnsNone needed
In their words

Hear it from the people taking it.

Videos from Yona customers, including Vagus+, the formula Vagus One grew out of. Individual experiences vary.

Real Yona customers

Thousands now eating with food freedom.

Most of them came to us for reflux.

More than four in five customers in our survey had acid or silent reflux when they started. Here’s what some of them say now.

Rated Excellent on Trustpilot

“I can eat anything I want”

I was suffering from acid reflux very often, sometimes I was choking in the middle of the night… I can eat anything I want without thinking about acid reflux.
Saintia M. · Trustpilot, April 2026

“Able to sleep lying down”

I have suffered with LPR (silent reflux) for 2 to 3 years… I’ve been taking them for around four months and I am now able to sleep lying down… most of the time.
Alison · Trustpilot, April 2026

“No cough, no throat clearing”

Having lived with LPR for 10 years, I’d lost all hope… No cough, no throat clearing and so, so happy.
Mel J. · Trustpilot, December 2025

“Night time reflux is much reduced”

I’ve tried all sorts of remedies over the years but for the first time in years I feel that this might actually help… night time reflux is much reduced.
Liz H. · Trustpilot, October 2025

“It took a few months, but I’d had it for years”

Great product that reduced my acid reflux massively. It took a few months, but I’d had it for years.
Mary H. · Trustpilot, June 2026

“Symptom free for the majority of the time”

I’ve now been on the supplement for silent reflux for a number of months. My symptoms have definitely improved. I’m now symptom free for the majority of the time… Don’t expect a fast cure but I do think it helps.
Sara · Trustpilot, May 2026

“The only product I’ve found that’s helped”

The only product I’ve found that’s helped my acid reflux. Also wonderful customer service.
Caroline S. · Trustpilot, March 2026

“Less bloating. A lot calmer.”

Within the first week I felt a massive difference and have continued using these daily. I have less bloating… Feeling a lot calmer too.
Kathleen M. · Verified review

“I’d had this problem for YEARS”

I have been taking these capsules for a few months to try and stop my excessive burping and after the second/third bottle I realised I’d virtually stopped burping completely.
LBM · Verified review, June 2026

“Nerves, stomach, sleep: all improved”

I was skeptical that this product could support me, but on reflection my general regulation — nerves, stomach, sleep — have all improved and I’ve felt supported.
Jules Z. · Verified review, April 2026

“I can feel the difference”

I have been taking it for nearly a month and I can feel the difference… less bloating, and don’t seem to get any acid indigestion.
Sally S. · Verified review

“Much more settled after 6 weeks”

I didn’t think this would work. I was very suspicious. However after 6 weeks I am much more settled and don’t have the gut issues.
Jane J. · Verified purchase

“A meal without the panic”

…to be able to have a meal and not panic about feeling uncomfortable afterwards.
Liz H. · Verified review

4.6 from 1,000+ reviews

A ninety-day routine, with a money-back promise if nothing changes.
Try it for 90 days

Reviews from Yona customers, including Vagus+, the formula Vagus One grew out of. Headlines are pulled from each review; trimmed for length where marked. Individual experiences vary.

From a former NHS doctor

“I watched patients stay on acid tablets for years longer than anyone planned. Nobody was asking what came next.”

Acid-suppressing tablets are good medicine. They turn the acid down fast, and at first that’s often exactly what’s needed.

But they were meant to manage reflux, not to be the whole plan. NICE guidance says long-term use should be reviewed every year. In clinic, I kept meeting people who’d been on them for years without that conversation ever happening.

Long-term use isn’t free, either. The MHRA has warned about low magnesium and a higher risk of fractures with prolonged use. Most of the people I saw had never been told.

We’re taking a stand against managing the acid forever and calling it a plan.

Don’t stop anything you’ve been prescribed. Do ask your GP for a review. And while you’re at it, feed the part of digestion no tablet reaches.

Sana MisraFormer NHS doctor
From a former NHS doctor

“As an NHS doctor, I treated bloating and bad sleep as two separate problems. I was wrong.”

Medicine is built to find disease, and it’s brilliant at it. But when nothing is seriously wrong, you get a fix for each symptom. Something for the gut. Something for sleep. Each treated as if the other didn’t exist.

Then I saw what they had in common. Digestion that changed with stress. Sleep that fell apart when people couldn’t unwind. Different symptoms, one trigger.

That isn’t a gut problem or a sleep problem. It’s a nervous system problem.

And the nerve that links them is the vagus nerve. More and more people are running short of the nutrients it needs.

That’s what led us to build Yona.

Sana MisraFormer NHS doctor
The clinicians who advise us
Dr Alisha Damani
Dr Alisha Damani
MBChB· Clinical adviser

Specialises in autonomic nervous system function and its effect on digestive health: the exact biology Vagus One is built around.

David McCollum
David McCollum
Cert Nat ANP· Clinical nutritionist

Twenty-five years in clinical nutrition, working with people who haven’t responded to conventional approaches.

The science

Over a century of research. One daily formula.

Vagus One is built on what physiology has known for more than a hundred years about the nerve that runs your digestion.

  1. 1921Your gut’s nerve has a messenger.

    Otto Loewi shows that the vagus nerve signals chemically. The messenger is acetylcholine, and the work wins a Nobel Prize.3

  2. 1943That messenger is built from nutrients.

    Acetylcholine is shown to be made from choline and an acetyl group. Later work ties that acetyl group to vitamins B1 and B5.4

  3. 2000sThe ingredients are tested in people.

    Citicoline, saffron and L-theanine go through randomised, placebo-controlled human trials.

What the research shows

Citicoline · 250 mg

In a double-blind trial of 60 women aged 40 to 60, 250 mg a day meant fewer attention errors than placebo after 28 days.5

Read the study
Saffron · 30 mg

In a double-blind trial of 128 adults, 28 mg a day improved mood scores against placebo. In a second trial at 30 mg, heart-rate variability held steady during a lab stress test, where it dropped on placebo.6

Study one Study two
Benfotiamine · 200 mg

In a human absorption study, benfotiamine raised blood thiamine far higher than standard thiamine.7

Read the study

40+ peer-reviewed studies behind the formula, 19 of them in people.

Start my 90 days See every study →
Questions

Questions people actually ask.

Will it work for me?
For most of our customers, digestion gets better: in our customer survey, four in five reported better digestion. Vagus One works on the nerve side of digestion. The vagus nerve sets the pace of your gut, from stomach acid to the waves that move a meal along, and it runs on specific nutrients. Vagus One supplies them every day. And your first 90-day supply comes with our money-back promise, so you can start with confidence.
What is Reflux Calm?
It’s the add-on we suggest alongside Vagus One for reflux, and it’s optional. Vagus One is nutrition for the nerve; Reflux Calm is our formula for the lining side: sodium butyrate, S. boulardii, zinc carnosine and bovine immunoglobulin. One 30-day bottle (90 capsules, three a day), usually £29. Tick the box in the order form and it’s free with your first 90-day supply, or £29 with the 30-day supply. One per order, not repeated on renewals, while stocks last. Vagus One is vegan; this add-on contains bovine-derived immunoglobulin, so it isn’t suitable for vegetarians or vegans.
What’s the optional Gut Repair+ add-on?
Vagus One is the plan, and for most people it’s all they’re here for. Gut Repair+ is a separate formula for anyone who’d also like support for the gut lining: sodium butyrate, S. boulardii, zinc carnosine and bovine immunoglobulin. If you want it, tick the box in the order form and one 30-day bottle (90 capsules, three a day), usually £29, is added free to your first 90-day supply on either plan. One per order, not repeated on renewals, while stocks last. Vagus One is vegan; Gut Repair+ contains bovine-derived immunoglobulin, so it isn’t suitable for vegetarians or vegans.
I take a daily tablet for acid. Is this instead of it?
No. Vagus One is a food supplement, not a medicine, and it doesn’t replace one. They work on different things: your tablet works on the acid, Vagus One is nutrition for the nerve side of digestion. Keep taking what you’ve been prescribed, and check with your GP or pharmacist before adding a supplement. Many of our customers were on acid medication when they started. Any change to yours is a decision for you and your GP.
Is this a probiotic?
No. There are no bacteria, enzymes or fibre in Vagus One. It’s nutrition for the nerve side of digestion: vitamins, amino acids and a plant extract. You can take it alongside a probiotic if you already use one. (The optional Gut Repair+Reflux Calm add-on does include S. boulardii, a yeast.)
Why would I need this if I already eat reasonably well?
Because most of what’s in Vagus One isn’t something you’d get from meals in these amounts, even eating well. Citicoline, acetyl-L-carnitine, L-theanine and saffron extract aren’t vitamins, and benfotiamine is a form of vitamin B1 your body absorbs far better than the standard kind. The B vitamins and magnesium alongside them are there because the nerve uses them together, in set daily amounts. A good diet is the foundation. Vagus One adds a steady daily supply of the nutrients this nerve runs on.
Does Vagus One stimulate the vagus nerve?
No, and that’s the point. Breathwork, cold water and devices stimulate the nerve: they ask it to fire. Vagus One is nutrition. It supplies what the nerve runs on, so it works alongside anything you already do.
How long until I notice a difference?
Most people who notice a change feel it within the first four weeks. It builds from there, because you’re supplying what the nerve runs on rather than forcing a response. That’s why Vagus One is designed as a 90-day routine.
When’s the best time to take it?
Two capsules daily, with a meal. If you’re sensitive to supplements, start with one capsule a day for the first few days.
Do I need to change what I eat?
No. A varied, balanced diet comes first, and if a food genuinely disagrees with you, keep avoiding it. Vagus One doesn’t ask you to cut anything out.
Can I take it with medication or other supplements?
Speak to your doctor or pharmacist first if you take prescription medication, are pregnant or breastfeeding, are under 18 or have a diagnosed condition. Check the amounts across any other supplements you use.
When should I see my GP instead?
If you have blood in your stools, unexplained weight loss, difficulty swallowing, severe or persistent pain, diarrhoea that lasts more than seven days, or a change in bowel habit that lasts three weeks or more, see your GP. Those need assessing, not a supplement.
Do I have to subscribe?
No. Choose One-time purchase for a single payment and nothing renews. A subscription renews at the price in your order summary (every three months for the 90-day supply, monthly for the 30-day), with no minimum term; you can pause, skip or cancel.
How does the 90-day promise work?
Take Vagus One every day for 90 days from delivery. If nothing has changed, email us between day 90 and day 120, answer a few short questions, and we’ll refund what you paid for that supply. There’s nothing to send back. The promise covers your first 90-day supply; the 30-day supply isn’t included.

You’ve tried everything else. Give the nerve ninety days.

Nine actives. Two capsules a day. One ninety-day routine.

Try Vagus One for 90 days

90-day money-back promise

  1. Overton E, Emelyanova A, Bunik VI. Thiamine, gastrointestinal beriberi and acetylcholine signaling. Frontiers in Nutrition. 2025;12:1541054. PubMed 40271433. Browning KN, Travagli RA. Central nervous system control of gastrointestinal motility and secretion. Comprehensive Physiology. 2014. PubMed 25428846.
  2. Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. Journal of Physiology and Pharmacology. 2011. PubMed 22314561.
  3. Loewi O. Über humorale Übertragbarkeit der Herznervenwirkung. Pflügers Archiv. 1921;189:239–242. doi:10.1007/BF01738910.
  4. Nachmansohn D, Machado AL. The formation of acetylcholine. A new enzyme: “choline acetylase”. Journal of Neurophysiology. 1943;6(5):397–403. doi:10.1152/jn.1943.6.5.397.
  5. McGlade E, Locatelli A, Hardy J, et al. Improved attentional performance following citicoline administration in healthy adult women. Food and Nutrition Sciences. 2012;3(6):769–773. doi:10.4236/fns.2012.36103.
  6. Kell G, Rao A, Beccaria G, et al. affron®, a novel saffron extract, improves mood in healthy adults over 4 weeks. Complementary Therapies in Medicine. 2017;33:58–64. doi:10.1016/j.ctim.2017.06.001. Jackson PA, Forster J, Khan J, et al. Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults. Frontiers in Nutrition. 2021;7:606124. doi:10.3389/fnut.2020.606124.
  7. Xie F, Cheng Z, Li S, et al. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. Journal of Clinical Pharmacology. 2014;54(6):688–695. doi:10.1002/jcph.261.

Cited as published research on the underlying biology, not as studies of Vagus One. Survey figures are self-reported: 128 responses from Yona customers, 2026.

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