Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
Vagus One. A Daily Vagus Nutraceutical Yona
4.6 from 1,000+ reviews

Vagus One

For a body that struggles to switch off.

Exhausted but wired Stress-reactive digestion Sleep that doesn't restore

Daily nervous-system nutrition, designed around the biology of the vagus nerve.

Backed by 40+ peer-reviewed studies. See the science
Choose your supply

That's £1.10 a day. Less than a coffee.

Ships from the UK · usually 2–3 days

Secure checkout

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  • Pause or cancel anytime
  • Third-party tested, every batch
  • Vegan. No fillers or flow agents

“My general regulation — nerves, stomach, sleep — have all improved.”

Jules Z · Verified review
Written and reviewed by the Yona formulation team — not a chatbot, and not medical advice. For anything about your own health, speak to your doctor or pharmacist.
Ingredients

Nine actives. Per 2 capsules:

  • Benfotiamine — 200 mg
  • Thiamine (as thiamine HCl) — 25 mg
  • Riboflavin (as riboflavin-5-phosphate) — 10 mg
  • Magnesium (as magnesium bisglycinate) — 60 mg
  • Citicoline — 250 mg
  • Pantothenic acid (B5) — 100 mg
  • Acetyl-L-carnitine — 300 mg
  • L-theanine — 150 mg
  • Saffron (standardised stigma extract) — 30 mg

Other ingredients: a vegan HPMC capsule, and nothing else. No microcrystalline cellulose, no magnesium stearate, no silicon dioxide.

How to take it

We recommend starting with one capsule a day for the first five days, then moving up to the standard daily dose of two. The gentler start gives your nervous system time to adjust.

  • Best taken with a meal earlier in the day.
  • If you would rather not swallow them, open the capsule and stir the powder into food or any drink.
  • Keep it where you eat, so it isn't a decision.
  • Give it a full 90-day cycle before judging it.

New to the vagus nerve? Read our guide to what it does and how to support it.

What's in it and what's not

Nine actives, independently tested for purity and potency before every batch ships.

Contains
  • Benfotiamine 200 mg + thiamine 25 mg + riboflavin-5-phosphate 10 mg + magnesium (as bisglycinate) 60 mg — the nerve layer
  • Citicoline 250 mg + pantothenic acid 100 mg + acetyl-L-carnitine 300 mg — the signal layer
  • L-theanine 150 mg + saffron 30 mg — the state layer
  • Saffron at 30 mg and citicoline at 250 mg — the amounts used in human research
  • A vegan HPMC capsule — and nothing else
Does not contain
FillersBindersBulking agentsMagnesium stearateMicrocrystalline celluloseSilicon dioxideCaffeineAdded sugarArtificial sweetenersArtificial coloursMelatoninSedativesGlutenDairy
Shipping & returns

Dispatched from the UK with Royal Mail or InPost. Estimated delivery is usually within 2–3 days of dispatch. There is an option for expedited shipping at checkout.

Any questions, message us on WhatsApp or email hello@meetyona.co.uk.

WhatsApp +44 7767 211135

The 90-day promise (90-Day Supply). Your 90 days start the day your order arrives. If nothing has changed after taking it every day for the full 90 days, email hello@meetyona.co.uk between day 90 and day 120 and answer a few short questions about how you took it. We'll refund what you paid for that supply — no need to send anything back. On a subscription, skip or cancel your next delivery before it bills if you plan to claim.

Science-led from the start

Built on decades of research into nervous-system nutrition, cholinergic biology and the stress response. Every ingredient has a defined role within our Nerve · Signal · State formulation.

  • Peer-reviewed research
  • Third-party tested, every batch
  • Doctor and nutritionist advised
Explore the science →
In a survey of 748 Yona customers

They told us where they felt it first.

Self-reported survey of Yona customers, 2026. Responses are individual experiences and results vary. Food supplements are not a substitute for a varied diet or prescribed medication.

Dr Alisha Damani David McCollum

Developed with a clinical advisory team spanning medicine and nutrition: Dr Alisha Damani, MBChB, and clinical nutritionist David McCollum.

  • 9 actives, three layers
  • GMP manufactured
  • No melatonin or sedatives
In their words

What people say after
a full cycle.

Where you notice it

Not in a lab. In an ordinary Tuesday.

A woman standing at her desk in evening light, closing her laptop for the day
Rest6:00 pm

The work is over. You'd like your body to feel like it is too.

A woman sitting back at the table after a meal, plate finished, at ease
Digest9:00 pm

Dinner's finished. You'd like to eat, finish and move on.

A woman at her bedroom window in morning light, bed still unmade behind her
RecoverThe next morning

You slept. You'd like to feel like it counted.

Three different moments. One nerve running all of them.

Why nutrition

One nerve. Nine places you feel it.

Its name means wandering. The vagus nerve runs from the base of the brain to nearly every system that decides whether your body stays switched on, or stands down. Read the full guide to the vagus nerve →

  • BrainstemWhere it begins. Most of its traffic runs upward, body to brain.
  • HeartThe brake between beats, and what heart-rate variability measures.
  • StomachAcid and the muscular waves that move a meal onward.
  • GutThe largest single source of the signals travelling up it. How your gut and brain talk
  • LungsAirway tone and breathing rhythm. Why a long exhale settles you.
  • ThroatSwallowing, and the sound of your own voice.
  • LiverHow the body keeps track of its own energy state.
  • PancreasEnzymes, and how the body responds when a meal arrives.
  • SpleenThe inflammatory reflex, a built-in brake, via the coeliac ganglion.
80%

of vagal fibres carry information from your organs up to your brain. Your body isn't only taking orders. It's reporting back, all day.

Stimulation

Asks the nerve to fire.

An input in the moment. Useful, and several are free. 11 methods, compared by the evidence

Long exhalesColdHummingDevices
Nutrition

Supplies what firing runs on.

Every day, underneath. Almost nobody is feeding it.

Neuronal energyCholineCofactorsCalm state

Vagus One is the nutrition half. Keep the breathwork. Add the fuel.

The formula

One nervous system. Three layers of support.

Per 2 capsules30 servingsVegan capsule
01

Nerve

Nutrients selected around normal nervous-system function and neuronal energy.

Benfotiamine200 MG
The fat-soluble form of B1, developed in Japan after chemists found thiamine hiding in garlic. Selected around thiamine-dependent energy metabolism in nerve cells.
Thiamineas thiamine HCl25 MG
Vitamin B1, the first vitamin ever isolated. The standard water-soluble form, working alongside the fat-soluble one.
Riboflavinas riboflavin-5-phosphate10 MG
Vitamin B2, from the Latin flavus, “yellow”. The 5-phosphate form, already activated, selected around energy metabolism in nerve tissue.
Magnesiumas magnesium bisglycinate60 MG
Bound to glycine, the smallest amino acid there is. Chelated for tolerability and selected around normal nervous-system function.
02

Signal

Built around the nutritional biology involved in acetylcholine signalling.

CiticolineCDP-choline250 MG
The intermediate every cell membrane is built through. Included at 250 mg, the amount used in human research, and selected around the choline side of the signal.
Acetyl-L-carnitine300 MG
Named from the Latin carnis, “flesh”, after chemists first drew it out of muscle in 1905. It carries acetyl groups itself.
Pantothenic acidvitamin B5100 MG
From the Greek pantothen, “from everywhere”. The precursor to coenzyme A, and the acetyl half of that same signal.
03

State

Human-studied bioactives selected around calm, the stress response and resilience.

L-theanine150 MG
Isolated from green tea in 1949, and the reason a cup of tea feels nothing like a cup of coffee. Selected to support a settled state without sedation.
Saffronstandardised stigma extract30 MG
Three stigmas per flower, picked by hand: the most expensive spice by weight in the world. Included at the 30 mg used in human research on mood and stress resilience.
The science

Every ingredient earns its place.

Nine ingredients, each chosen from peer-reviewed research for a defined role. Every ingredient, every dose, every reason.

  • 40+peer-reviewed studies behind the formula
  • 100+years of nervous-system research
  • 19studies in people

Explore the science behind Vagus One

Nothing else

Most capsules carry three passengers. Ours carries none.

Turn most supplement bottles round and you'll find the same three names under “other ingredients”. None of them is there for you. They're there for the factory: to pad a capsule out to size, and to keep powder running through the machine.

Filler

Microcrystalline cellulose

Refined wood pulp, used to bulk a capsule out. It does nothing for your nervous system, so it isn't in ours.

Flow agent

Magnesium stearate

A lubricant that stops powder sticking to machinery. In lab tests it can slow how quickly a capsule's contents dissolve. Not the magnesium in our formula: that's bisglycinate.

Anti-caking agent

Silicon dioxide

Nano-sized silica that keeps powder free-running. A 2024 mouse study found daily exposure lowered the gut's tolerance to food proteins.

That research is early, and all three are still permitted in supplements. Our rule is simpler: if it isn't there for you, it isn't in the capsule.

No caffeine, melatonin or sedatives. Vegan HPMC capsule. Third-party tested, every batch · GMP manufactured
Where it fits

Most approaches cover one layer. Vagus One covers three.

You may already use some of these. They can all be useful. Here's what each one is actually built to reach.

ApproachNerveSignalStateWorth knowing
Magnesium aloneMineralA genuine nervous-system nutrient. It's one of four actives in our nerve layer, not the whole answer.
B-complexVitaminsBroad energy metabolism across the whole body, rather than dosed around neuronal energy.
AdaptogensBotanicalsWork on the stress-hormone response: how hard the system reacts, not what it runs on.
Breathwork, cold, devicesStimulationAn immediate input, in the moment. Keep doing them. They're a different layer, not a rival. See all 11 compared
Vagus OneNervous-system nutritionNine actives across all three layers, daily, from £1.10 a day. Not a sedative, sleep aid or device.
Built for itPartlyNot what it's for
The guides

Learn more about the vagus nerve. The longest cranial nerve in your body.

All guides →
01Start here

The vagus nerve

What it does, the signs it's struggling, and how to support it.

Read the guide → 02

Signs of low vagal tone

What it feels like day to day, and what actually helps.

Read the guide → 03

11 ways to stimulate it, compared

Breathing, cold, devices and more, ranked by the evidence.

Read the guide → 04

The vagus nerve and digestion

How your gut and brain talk, and why stress lands in your stomach.

Read the guide →
Reviews

1,000+ reviews. Here's what people keep saying.

4.6
★★★★★

From 1,000+ reviews

“Ten years of gut issues… I’ve tried a lot of different things over the years, and there’s only a handful that I can say made a tangible, measurable difference. The longer I take it, the better I feel.”
YM
Yvonne M.On camera, in her own words
★★★★★Switching off
“I was skeptical that this product could support me, but on reflection my general regulation — nerves, stomach, sleep — have all improved and I’ve felt supported.”
Jules ZVerified buyer · Apr 2026
★★★★★Digestion
“I have been taking these capsules for a few months to try and stop my excessive burping and after the second/third bottle I realised I’d virtually stopped burping completely. I’ve had this problem for YEARS.”
LBMVerified buyer · Jun 2026
★★★★★Switching off
“Before I started taking Yona I would get upset very quickly, now I am more relaxed. I also have more motivation to do things where before I couldn’t be bothered.”
Eileen B.Verified buyer
★★★★★Digestion
“Great product that reduced my acid reflux massively. It took a few months, but I’d had it for years.”
Mary HaleyVerified buyer · Jun 2026
★★★★★Sleep
“The best thing is being able to sleep without the fear of waking up with reflux, and to be able to have a meal and not panic about feeling uncomfortable afterwards.”
Liz H.Verified buyer
★★★★★Recovery
“After suffering fatigue and erratic bowels for weeks after a really aggressive gut bug, Yona really aided recovery… support and reassurance that symptoms would recover in time.”
Philippa RayneVerified buyer · Aug 2026
★★★★★4–5 months in
“I have been using Yona for 4/5 months now and noticed a difference not only in my reflux but my day to day feelings.”
Ben SweeneyVerified buyer · Jun 2026
★★★★★Digestion
“Within the first week I felt a massive difference and have continued using these daily. I have less bloating… Feeling a lot calmer too.”
Kathleen MonaghanVerified buyer · Aug 2024
★★★★★Digestion
“I was suffering from acid reflux very often, sometimes I was choking in the middle of the night… I can eat anything I want without thinking about acid reflux. My digestion feels better.”
Saintia MapukuVerified buyer · Apr 2026
★★★★★Digestion
“I have been taking it for nearly a month and I can feel the difference… less bloating, and don’t seem to get any acid indigestion.”
Sally S.Verified buyer
★★★★★Honest take
“My symptoms have definitely improved. I’m now symptom free for the majority of the time… Don’t expect a fast cure but I do think it helps.”
SaraVerified buyer · May 2026

Reviews from Yona customers, including Vagus+, the formula Vagus One grew out of. Trimmed for length where marked; otherwise in the words they were written in.

Read all reviews Start your 90 days
Verified

Reviews from Yona users.

Previously called Vagus+ — the formula Vagus One grew out of.

The 90-day routine

Ninety days. One simple routine.

Nervous-system nutrition is a daily practice, not a quick fix. Vagus One is designed to be taken every day, which is why the most complete way to begin is 90 days, backed by our 90-day promise. Here's how it tends to unfold, drawn from what 748 customers told us.

Days 1–5 1 capsule with a meal From day 6 2 capsules, same meal Tip Open one into food or a drink
  1. Weeks 1–2

    Laying the foundation.

    You're supplying raw materials, not taking a sedative. The only job is not missing days.

  2. Weeks 3–4

    The evening goes first.

    Where people notice something, it tends to show up at night. 64% of those who noticed a change did so within four weeks.

    “I have been taking it for nearly a month and I can feel the difference… less bloating.”Sally S. · Verified buyer
  3. Month 2

    It stops being a decision.

    The capsules are part of a meal, not a task. What changes tends to arrive as a new baseline, not an event.

    “After 6 weeks I am much more settled and don’t have the gut issues.”Jane J. · Verified buyer, Vagus+
  4. Month 3

    A settled routine.

    A pattern that took years to set doesn't shift in three weeks. Ninety days gives a daily routine time to become your baseline, and it's covered by our 90-day promise.

    “It took a few months, but I’d had it for years.”Mary Haley · Verified buyer

It's for you if…

Not sure? Read the signs of low vagal tone →

  • You get to the end of the day and still can't come down.
  • Your digestion tracks your stress a little too closely.
  • You sleep the hours but don't wake up restored.
  • You already breathe, plunge or hum, and want the other half of it.

It's not for you if…

  • You want something that knocks you out. No melatonin, no sedatives.
  • You want to feel it by Friday. This is cumulative.
  • You expect it to fix a diagnosed condition. It's food, not treatment.
  • You're pregnant, breastfeeding, under 18 or on prescription medication. Ask your doctor first.
Who's behind it

The people behind it. And the clinicians who check it.

Sana Misra, co-founder of Yona
A note from our co-founder

“What if these aren’t separate problems?”

I worked as a doctor in the NHS. Medicine is brilliant at diagnosing and treating disease, but we often treat the symptom in front of us. Bloating? Something for the gut. Can’t sleep? Something for sleep.

I kept seeing the same pattern: digestion that changed with stress, sleep that fell apart when people couldn’t unwind. That question led me to the nervous system and the vagus nerve, where almost everything people were doing was stimulation, and hardly anyone talked about what the nerve runs on.

I still tell people to see their GP, especially if something’s new or getting worse. I just don’t think the conversation should stop at the symptom. That’s why we built Yona.

Sana MisraCo-founder, Yona · Former NHS doctor

Dr Alisha Damani
Dr Alisha DamaniMBChB · Clinical advisor

Specialises in autonomic nervous system function and its effect on digestive health, the exact biology Vagus One is built around. Her role is the reality check.

David McCollum
David McCollumCert Nat ANP · Clinical nutritionist

Twenty-five years in clinical nutrition, working in complex digestive dysfunction and nervous-system recovery. He brings the casework.

The 90-day promise
  1. 1Take it every day for 90 days. The clock starts when your order arrives.
  2. 2Nothing changed? Email us between day 90 and day 120 and answer a few short questions.
  3. 3We refund what you paid for that supply. No need to send anything back.
Covers your first 90-Day Supply. On a subscription, skip or cancel your next delivery before it bills if you plan to claim.
Before you decide

The questions people actually ask.

Pause or skipPush a delivery back or skip it. Your price doesn't change.
Cancel in one clickNo minimum term, no fee, nobody to persuade.
Or don't subscribeBuy a single supply. Subscribing is a discount, not a requirement.

Still unsure? WhatsApp us or email hello@meetyona.co.uk.

Does Vagus One stimulate the vagus nerve?

No. Breathwork, cold and devices stimulate it: they ask it to fire. Vagus One is nutrition. It supplies nutrients and bioactives selected around the biology the nerve runs on. Stimulation is one layer; nutrition is another, and we'd rather you did both. Compare the 11 stimulation methods.

What's the science behind Vagus One?

Over a century of nervous-system science, curated into one formula. Every ingredient was chosen from peer-reviewed research, more than 40 studies in all, and each has a defined role across Nerve, Signal and State. Explore the science.

Who is it designed for?

People who recognise the feeling: “My body struggles to switch off.” Tired but still on, stress-reactive digestion, restless evenings, sleep that doesn't restore. A body that's very good at switching on, and struggles to switch back. Read the signs of low vagal tone.

Why not just take magnesium?

Magnesium is in it: 60 mg, as bisglycinate. But it's one of nine. Vagus One pairs it with the B-vitamin, choline and calm-state layers, rather than relying on one ingredient alone. If magnesium on its own already helps you, that's a reason to expect more here, not less.

Why are there no fillers or flow agents in it?

Most capsules carry microcrystalline cellulose, magnesium stearate and silicon dioxide: a filler, a lubricant and an anti-caking agent. They make manufacturing faster. They do nothing for you, and early research has started asking questions about them, silicon dioxide and the gut in particular. Vagus One has none of the three: nine actives in a vegan capsule, and nothing else.

Will it make me sleepy or wired?

Neither. There's no melatonin, valerian or caffeine. It's a daily foundation, not something that knocks you out or gives you a buzz. The State layer, L-theanine and saffron, is there so it never feels like a stimulating nootropic.

How quickly will I notice something?

Most people who notice something do so within the first three to four weeks, usually in the evening first. Some people notice nothing, and we'd rather say that here. Give it the full 90 days; the promise covers you if nothing changes.

What if I'm sensitive to supplements?

Take it gradually: one capsule a day for the first five days, then two when you're ready. You can also open a capsule into food or a drink. If you're unsure at any point, message us.

Can I take it alongside medication?

Ask your doctor or pharmacist first, particularly if you take prescribed medication, are pregnant or breastfeeding, or have an existing condition. Take the bottle: it lists every active and exactly how much. Never stop or reduce prescribed medication because you've started a supplement.

How does the subscription work?

The 30-day arrives monthly, the 90-day every three months. It's cheaper because a predictable order costs us less to fulfil. There's no minimum term: pause, skip or cancel from your account, without emailing anyone.

How long does delivery take?

Dispatched from the UK with Royal Mail or InPost, usually within 2–3 days, with expedited shipping available at checkout.

Vagus One 90-Day Supply: one bottle and two refills
Daily nervous-system nutrition

One nerve runs rest, digestion and recovery. Feed it.

  • Nine actives across Nerve · Signal · State
  • 4.6★ from 1,000+ reviews
  • 90-day promise: nothing changed, we refund what you paid
£1.10a day · less than a coffee · 90-Day Supply, subscribed
Start your 90 days Find your vagus pattern
Vagus One